Lepist, Eve: search on Z-Library

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1

Renal drug–drug interactions: what we have learned and where we are going

Lepist, Eve-Irene, Ray, Adrian S

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2012

Language:

english

File:

PDF, 392 KB

english, 2012

2

Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor

Chandrasekhar, Jayaraman, Dick, Ryan, Van Veldhuizen, Joshua, Koditek, David J, Lepist, Eve-Irene, McGrath, Mary E., Patel, Leena, Phillips, Gary, Sedillo, Kassandra, Somoza, John R., Therrien, Joseph

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.97 MB

english, 2018

3

Evaluation of the Endothelin Receptor Antagonists Ambrisentan, Bosentan, Macitentan, and Sitaxsentan as Hepatobiliary Transporter Inhibitors and Substrates in Sandwich-Cultured Human Hepatocytes

Lepist, Eve-Irene, Gillies, Hunter, Smith, William, Hao, Jia, Hubert, Cassandra, St. Claire, Robert L., Brouwer, Kenneth R., Ray, Adrian S., van Veen, Hendrik W.

Journal:

Year:

2014

Language:

english

File:

PDF, 878 KB

english, 2014

4

Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-Induced Inflammation in Rats

Siddharth Sukumaran, Eve-Irene Lepist, Debra C. DuBois, Richard R. Almon, William J. Jusko

Journal:

Pharmaceutical Research

Year:

2012

Language:

english

File:

PDF, 295 KB

english, 2012

5

Stability and in vitro metabolism of dipeptide model prodrugs with affinity for the oligopeptide transporter

Eve-Irene Lepist, Tina Kusk, Dorrit H Larsen, Dorthe Andersen, Sven Frokjaer, Mitchell E Taub, Peep Veski, Hans Lennernäs, Gerda Friedrichsen, Bente Steffansen

Journal:

European Journal of Pharmaceutical Sciences

Year:

2000

Language:

english

File:

PDF, 114 KB

english, 2000

6

Implications of Efficient Hepatic Delivery by Tenofovir Alafenamide (GS-7340) for Hepatitis B Virus Therapy

Murakami, Eisuke, Wang, Ting, Park, Yeojin, Hao, Jia, Lepist, Eve-Irene, Babusis, Darius, Ray, Adrian S.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

7

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)

Liang, Xiaomin, Chien, Huan-Chieh, Yee, Sook Wah, Giacomini, Marilyn M., Chen, Eugene C., Piao, Meiling, Hao, Jia, Twelves, Jolyn, Lepist, Eve-Irene, Ray, Adrian S., Giacomini, Kathleen M.

Journal:

Molecular Pharmaceutics

Year:

2015

Language:

english

File:

PDF, 2.35 MB

english, 2015

8

Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856

Perreault, Stephane, Chandrasekhar, Jayaraman, Cui, Zhi-Hua, Evarts, Jerry, Hao, Jia, Kaplan, Joshua A., Kashishian, Adam, Keegan, Kathleen S., Kenney, Thomas, Koditek, David, Lad, Latesh, Lepist, Eve

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 774 KB

english, 2017

9

Stability, metabolism and transport of d-Asp(OBzl)–Ala — a model prodrug with affinity for the oligopeptide transporter

Bente Steffansen, Eve-Irene Lepist, Mitchell E. Taub, Bjarne D. Larsen, Sven Frokjaer, Hans Lennernäs

Journal:

European Journal of Pharmaceutical Sciences

Year:

1999

Language:

english

File:

PDF, 102 KB

english, 1999

10

Response to the Letter to the Editor by Stephen Toovey and Andrew Jamieson

Toufigh Gordi, Eve-Irene Lepist

Journal:

Toxicology Letters

Year:

2004

Language:

english

File:

PDF, 34 KB

english, 2004

11

Discovery of an Atropisomeric PI3KÎ² Selective Inhibitor through Optimization of the Hinge Binding Motif

Perreault, Stephane, Arjmand, Fatima, Chandrasekhar, Jayaraman, Hao, Jia, Keegan, Kathleen S., Koditek, David, Lepist, Eve-Irene, Matson, Clinton K., McGrath, Mary E., Patel, Leena, Sedillo, Kassandra

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

File:

PDF, 2.01 MB

2020

12

Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat

Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P, Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S

Journal:

Kidney International

Year:

2014

Language:

english

File:

PDF, 778 KB

english, 2014

13

Stability and perfusion studies of Desmopressin (dDAVP) and prodrugs in the rat jejunum

Eve-Irene Lepist, Jesper Østergaard, Karin Fredholt, Hans Lennernäs, Gitte Juel Friis

Journal:

Experimental and Toxicologic Pathology

Year:

1999

Language:

english

File:

PDF, 860 KB

english, 1999

14

Artemisinin derivatives: toxic for laboratory animals, safe for humans?

Toufigh Gordi, Eve-Irene Lepist

Journal:

Toxicology Letters

Year:

2004

Language:

english

File:

PDF, 127 KB

english, 2004

15

Pharmacokinetics of cobicistat boosted-elvitegravir administered in combination with rosuvastatin

Custodio, Joseph M., Wang, Hui, Hao, Jia, Lepist, Eve-Irene, Ray, Adrian S., Andrews, Jessica, Ling, Kah Hiing J., Cheng, Andrew, Kearney, Brian P, Ramanathan, Srinivasan

Journal:

Journal of Clinical Pharmacology

Year:

2014

Language:

english

File:

PDF, 237 KB

english, 2014

16

Renal Transporter-Mediated Drug-Drug Interactions: Are They Clinically Relevant?

Lepist, Eve-Irene, Ray, Adrian S.

Journal:

Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 127 KB

english, 2016

17

Beyond drug-drug interactions: effects of transporter inhibition on endobiotics, nutrients and toxins

Lepist, Eve-Irene, Ray, Adrian S.

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2017

Language:

english

File:

PDF, 1.39 MB

english, 2017

18

2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors

Patel, Leena, Chandrasekhar, Jayaraman, Evarts, Jerry B, Haran, Aaron, Ip, Carmen, Kaplan, Joshua, Kim, Musong, Koditek, David J, lad, latesh, Lepist, Eve-Irene, McGrath, Mary E., Novikov, Nikolai, Pe

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.19 MB

english, 2016

19

Discovery of Orally Efficacious Phosphoinositide-3-Kinase delta Inhibitors with Improved Metabolic Stability

Patel, Leena, Chandrasekhar, Jayaraman, Evarts, Jerry B, Forseth, Kristen, Haran, Aaron C., Ip, Carmen, Kashishian, Adam, Kim, Musong, Koditek, David J, Koppenol, Sandy, Lad, Latesh, Lepist, Eve-Irene

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 916 KB

english, 2016

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